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Documentation · Guides

SAAM II™ tutorials.

Step-by-step PDF guides for building, fitting, and reporting compartmental models in SAAM II — from first install through advanced features. Click any tutorial to download the PDF directly.

Basic compartmental

9 PDFs · Foundational

Start here. These nine guides walk you through SAAM II's core workflow — model construction, data handling, parameter setup, fitting, plotting, and report writing.

  1. Intro
  2. Getting Started
  3. Working with Data
  4. Inputs
  5. Parameters
  6. Samples (PK/PD and AUC)
  7. Plotting
  8. Tables
  9. Writing Reports

Tutorial support files (sample data & pre-built model files): Download ZIP →

Advanced compartmental

Full documentation

For modelers ready to push beyond the basics. Covers if-then logic, change conditions, zero-order and pump inputs, delays, experimental inputs, deconvolution, forcing functions, Bayesian estimation, and multiple-solution analysis.

↓Download full documentation (PDF)

Converting rate constants K to clearances CL (PDF) →

Numerical mode

Getting started

Introduction to SAAM II's Numerical mode — for custom mathematical models, equation-driven workflows, and analyses that don't fit the compartmental paradigm.

↓Download getting started (PDF)

List of available mathematical functions (PDF) →

PopKinetics

Two-stage population analysis

PopKinetics tutorials and worked simulation examples for two-stage population-PK analysis with SAAM II.

↓Download PopKinetics ↓Download documentation (PDF) ↓Download tutorial files

Key references

Alternative Approaches to Estimation of Population Pharmacokinetic Parameters: Comparison with the Nonlinear Mixed-Effect Model
Drug Met Review · Steimer et al · 2008
A Bayesian approach to nonlinear random effects models
Biometrics · A Racine-Poon · 1985
Population Pharmacokinetic and Pharmacodynamic Modeling
Applications of Pharmacokinetic Principles in Drug Development · Jeliffe et al. · 2004
The iterative two-stage population approach to IVGTT minimal modeling: improved precision with reduced sampling. Intravenous glucose tolerance test
Am J Physiol Endocrinol Metab · Vicini & Cobelli · 2001
Semimechanistic population pharmacokinetic modeling to investigate amyloid beta trafficking and accumulation at the BBB endothelium
Mol Pharm · Wang et al. · 2021
Performance of an iterative two-stage Bayesian technique for population pharmacokinetic analysis of rich data sets
Pharm Res · Proost & Eleveld · 2006

An new version of PopKinetics is in the works - email us saam2@nanomath.us if you'd like to be notified when it's released.

↓Request SAAM II