Automated Glucose and C-peptide Minimal Model Analysis for IVGTT Data
For research teams running frequently sampled IVGTTs, AOMM™ IVGTT fits the glucose minimal model and the C-peptide minimal model from a spreadsheet, in batch, and reports insulin sensitivity, glucose effectiveness, β-cell responsivity and disposition indices with their precision.
Standard and insulin-modified protocols. Verified subject by subject against published estimates and against SAAM.
Standalone Windows app (AOMM™ not required). Runs locally; data stay with you.
Tech specs
AOMM™ IVGTT v1.2Test
Frequently sampled intravenous glucose tolerance test: standard, or insulin-modified (insulin injection at about 20 min).
The glucose model uses the measured insulin, injected insulin included, so no protocol setting is needed. Total β-cell responsivity is not reported for the insulin-modified protocol.
Inputs
Excel or CSV: one sheet per analyte (as SAAM input workbooks), the AOMM™ batch layout, or one row per sample.
Glucose (mg/dL or mmol/L), insulin (µU/mL or pmol/L), C-peptide (pmol/L, nmol/L or ng/mL); sampling times in minutes (any schedule); glucose dose (g/kg, default 0.3); age and BMI for the C-peptide kinetics. Units are read from the headers or confirmed on load.
Engine
SAAM numerical engine with the SAAM minimal-model reference studies, unchanged. One study per subject and model; weighted non-linear least squares; automatic refit from the last estimates when a fit stops at the iteration limit.
Quality control
Precision of each index for each subject as coefficient of variation (CV). Fits at a parameter bound are flagged; refits are logged.
Glucose minimal model14 parameters
- Insulin sensitivity (SI)
- Glucose effectiveness (SG)
- Remote insulin action rate (p2)
- Glucose distribution volume (V)
C-peptide minimal model25 indices
- First-phase β-cell responsivity (Φ1)
- Second-phase β-cell responsivity (Φ2)
- Basal β-cell responsivity (Φb)
- Total β-cell responsivity (Φtot)
- Basal and model insulin secretion rate
2.Toffolo G, De Grandi F, Cobelli C. Estimation of β-cell sensitivity from intravenous glucose tolerance test C-peptide data. Diabetes. 1995;44(7):845–854. C-peptide kinetics from Van Cauter et al., Diabetes 1992.
Disposition indices3 indices
- First-phase (DI1)
- Second-phase (DI2)
- Total (DItot)
Outputs
One results table (all indices with CV, inputs used, notes), fitted curves and plots, and the generated SAAM studies, which open in SAAM for inspection.
System
Windows 10/11 (64-bit). Standalone: AOMM™ and .NET are not required. Licensed per computer.